Scientists from the Francis Crick Institute and Imperial College London have investigated how munching on greens could help maintain a healthy gut.
The study found that mice fed on a diet rich in the compound I3C (Indole-3-carbinol) found in green vegetables, were greater protected from gut related illnesses. When vegetables such as broccoli are eaten, I3C is produced - activating the protein AhR (aryl hydrocarbon receptor). This receptor then passes signals to immune and tissue cells on the gut lining.
Group leader at the Francis Crick Institute, Dr Gitta Stockinger said: “Many vegetables produce chemicals that keep AhR stimulated in the gut. We found that AhR-promoting chemicals in the diet can correct defects caused by insufficient stimulation.”
Damaged cells that are unable to absorb nutrients or secrete protective mucus are then repaired. However, when these cells are left damaged, they divide uncontrollably, which can lead to bowel cancer.
Cancer Research UK’s expert on diet and cancer, Professor Tim Key said: “This adds to the evidence that a healthy diet, rich in vegetables, is important.”
The study is now preparing to see if the same results appear in people. Professor Key adds: “in the meantime there are plenty of good reasons to eat more vegetables.”